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Avasimibe Avasimibe inhibits ACAT with IC50 of 3. 3 μM, also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2. 5 μM, respectively. Avasimibe inhibits human P450 isoenzymes, particularly CYP2C9, CYP1A2 and CYP2C19, with an IC50 of 2.
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5 µM, respectively. These enzymes are responsible for a variety of oxidative metabolic reactions, particularly those that involve xe.